Overview


 

 

The nature and origin of consciousness has been an intriguing target of philosophical inquiry for millennia. Today, we view consciousness as an emergent phenomenon of neurobiological processes. Accordingly, the neuronal basis of consciousness has become a fundamental target for neuroscience research.

One way to study the neuronal basis of consciousness is by altering it, for example, by the application of anesthetics. With anesthetic drugs, one is able to adjust the level or state of consciousness reversibly, in a controlled manner. Comparing this investigational model with other forms of altered states of consciousness; for example, dreamless sleep or neurological disorder, provides a systematic approach to determine the critical neuronal processes that are responsible for the emergence or failure of consciousness.

Our laboratory focuses on investigating the effect of general anesthetics on neuronal function. This work includes experimental electrophysiology in small animals and human neuroimaging. Further detail about the current research projects is here .

Our research is also part of the wider research efforts of the Department of Anesthesiology and the Center for Consciousness Science at the University of Michigan Medical School. The Center is investigating consciousness from a multitude of viewpoints using various methodologies that range from experimental to clinical neuroscience, cognitive psychology, neuroimaging, electrophysiology, and brain-computer interfacing.

Understanding how general anesthetics modulate consciousness is important clinically. A major goal of research is to develop better technologies to monitor the level of consciousness in neurological patients with disorder of consciousness and in patients undergoing surgical anesthesia as well as to develop anesthetic drugs that selectively suppress consciousness without harmful side effects.

Discovering the neuronal basis of consciousness also has broad significance for the advancement of diagnosis and treatment of many neurologic and psychiatric disorders. Ultimately, understanding the mechanistic basis of conscious control of behavior should have a fundamental impact on personal responsibility, morality, law, and society in general. The outlook for creating artificial consciousness in the future puts this question in an even more important context.

 

 

 

 Current Research Projects


 

Functional connectivity in neuronal circuits

 

Information processing in neuronal ensembles

 

Mesoscopic dynamics

 

Large-scale connectivity

 

 

 

 

Emerging Projects


 

Currently under development are experimental approaches to examine how top-down, bottom-up, and local state modulation by anesthetics may alter cortical neuronal interactions associated with loss and return of consciousness.

 

Click here to learn more

 

 

 

 

 

Positions/Opportunities


 

Please contact us if you are interested in our research and would like be a part of our lab.

 

Employment Positions Available

Advanced research position in experimental electrophysiology coming soon. Click here to apply.

 

 

Graduate student position available.  Required background in physics, mathematics, or engineering.  Please send curriculum vitae to Kathy Zelenock.

 

Volunteer Opportunities Available

Our lab welcomes students who are looking for a volunteer opportunity. Student must have a strong science background and a desire to do neuroscience research/analysis. Please contact us for more information.

 

 

 

 

About Us


 

Zirui Huang, PhD

Research Fellow

Kathy Zelenock, MS

Administrative/Research Assistant

 

Shiyong Wang, MD

Research Specialist

 

 

 

Kathryn Mirandette, BS

Biomedical Engineering Student

 

 

 

 

Teaching Activities


 

Current

9/2017-12/2017
Cognitive Neuroscience of Consciousness (NS704), Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI

 

 

Past Teaching Activities

12/2017
Circuits and Computational Neuroscience (NS613), Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI

1/2017-5/2017
Supervised Research (APPPHYS715), Applied Physics Graduate Program, University of Michigan, Ann Arbor, MI

9/2016-12/2016
Cognitive Neuroscience of Consciousness (NS704), Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI

9/2016-12/2016
Student Research Rotation (NS801), Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI

11/2015
Consciousness and Neuronal Dynamics: Lessons from Anesthesia, University of Michigan Quantitative Biology Seminar, Ann Arbor, MI

 

 

 

Links


 

Plenary lecture at the Science of Consciousness meetingPodcast for the article of the month in Anesthesia and Analgesia

 

The University of MichiganDepartment of AnesthesiologyCenter for Consciousness ScienceAnesthesiology Basic ResearchNeuroscience Graduate ProgramBiomedical Engineering Applied Physics Program

 

 

 

 

Recent Publications


 

 

 

 

 

 

 

 

All Publications

 

 

 

 

Dr. Anthony G. Hudetz

Dr. Hudetz studied physics at Eötvös Loránd University , Budapest, Hungary, subsequently studied medical physiology at Semmelweis University of Medicine , Budapest, Hungary. He obtained Dr. Biologiae Medicinalis degree in 1979 and PhD in medical science in 1985. He has held faculty positions in the Department of Physiology, Semmelweis University of Medicine (1986-1987), the Department of Biomedical Engineering, Louisiana Tech University (1987-1989), the Department of Physiology, Medical College of Wisconsin (1989-1991), the Department of Anesthesiology, Medical College of Wisconsin (1991-2015), and the Department of Anesthesiology, University of Michigan (2015-date).

Dr. Hudetz has conducted research in physiology and neuroscience for four decades; the NSF and NIH has funded his work for more than twenty years. He has published over 142 articles and edited two books. He has held offices in scientific societies (Treasurer, Microcirculatory Society, Secretary and President, International Society on Oxygen Transport to Tissue). He currently serves on the editorial board of the journal Brain Connectivity. Dr. Hudetz organized two international conferences: the 25th Annual Meeting of the International Society on Oxygen Transport to Tissue, in Milwaukee, WI, 1997, and the 8th International Symposium on Memory and Awareness in Anesthesia, in Milwaukee, 2011. He has been serving as reviewer of grant applications for the NIH and NSF. His work on the problem of consciousness and anesthesia has been highlighted in the media .

 

 

 

 

 

 

Contact Us


 

Anthony G. Hudetz

Med Sci Office Phone:
734-615-3776
Med Sci Office Fax:
734-764-9332
Domino’s Farms Office Phone:
734-998-1435

Email:
ahudetz@med.umich.edu

Lab Office Address:

University of Michigan
Department of Anesthesiology Research
Medical Science Building 1 Office 7445C
1150 W. Medical Center Dr.
Ann Arbor, MI 48109-5615

Domino’s Farms Address:

Domino’s Farms
University of Michigan
Center for Consciousness Science
Lobby M, Suite 3100, Office 2130
24 Frank Lloyd Wright Dr.
Ann Arbor, MI 48106

 

Kathy A. Zelenock

Med Sci Office Phone:
734-763-5551
Domino’s Farms Office Phone:
734-998-7131
Email:
careyka@med.umich.edu

Hudetz Lab Address:
University of Michigan
Department of Anesthesiology Research
Medical Science Building 1 Room 7445
1150 W. Medical Center Dr.
Ann Arbor, MI 48109-5615

Lab mailing Address:
University of Michigan
Department of Anesthesiology Research
Medical Science Building 1 Room 7433
1150 W. Medical Center Dr.
Ann Arbor, MI 48109-5615